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目的探讨salusin-α水平与冠心病冠脉病变稳定性、严重程度及冠心病危险因素的关系。方法选择住院的122例经冠状动脉造影确诊的冠心病患者作为病例组,病例组再分别根据临床类型、冠脉病变支数、Gensini积分分为若干个亚组;门诊健康受试者60例作为对照组。所有受试者均测定外周血salusin-α水平及一般生化指标,收集一般临床资料。结果冠心病患者外周血salusin-α水平明显低于正常对照组[(0.50±0.18)ng/mlvs(0.69±0.23)ng/ml,P<0.01]。急性冠脉综合征患者salusin-α水平明显低于稳定性心绞痛患者[(0.46±0.17)ng/mlvs(0.56±0.19)ng/ml,P<0.01];Salusin-α水平在Gensini积分0～20组、20～40组和≥40组3组间无统计学差异,在单支病变组、双支病变组、三支病变组间亦无统计学差异。结论冠心病患者salusin-α水平可能与冠脉病变的稳定性相关,但不能反映冠脉粥样硬化病变的严重程度。
Objective To investigate the relationship between salusin-α level and coronary artery disease severity, severity and coronary heart disease risk factors. Methods A total of 122 coronary heart disease patients diagnosed by coronary angiography were selected as the case group. The cases were divided into several subgroups according to the clinical type, the number of coronary lesions and the Gensini score. Sixty healthy outpatients Control group. All subjects were measured in peripheral blood salusin-α levels and general biochemical indicators, to collect general clinical data. Results The level of salusin-α in peripheral blood of patients with coronary heart disease was significantly lower than that of the control group [(0.50 ± 0.18) ng / ml vs (0.69 ± 0.23) ng / ml, P <0.01]. The level of salusin-α in patients with acute coronary syndrome was significantly lower than that in patients with stable angina [(0.46 ± 0.17) ng / ml vs (0.56 ± 0.19) ng / ml, P <0.01] There was no significant difference between the three groups in the group of 20-40 and the group of ≥40. There was no significant difference between the single vessel disease group, the double vessel disease group and the triple vessel disease group. Conclusion The level of salusin-α in patients with coronary heart disease may be related to the stability of coronary lesions, but can not reflect the severity of coronary atherosclerosis.