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本文报道39例成人难治性急性白血病患者序贯应用左旋门冬酰胺酶和大剂量氨甲喋呤治疗的结果。39例中,男27例,女12例,年龄16～67岁,中位数25岁。其中急淋21例,急性未分化型白血病7例,急粒11例。方法所有患者第1天用氨甲喋呤50～80mg/M~2,3小时后静注左旋门冬酰胺酶4万IU/M~2,第8天静注氨甲喋呤120mg/M~2,24小时后再用左旋门冬酰胺酶。这种2天疗法每7～14天重复1次。每疗程氨甲喋呤增加40mg/M~2,直到不能耐受。左旋门冬酰胺酶
This article reports the results of 39 consecutive cases of adult refractory acute leukemia treated with L-asparaginase and high-dose methotrexate. In 39 cases, 27 males and 12 females, aged 16 to 67 years, median 25 years old. Of which 21 cases of acute leaching, acute undifferentiated leukemia in 7 cases, 11 cases of acute particles. Methods All patients on the first day with methotrexate 50 ~ 80mg / M ~ 2,3 hours after intravenous levamisopectin 40,000 IU / M ~ 2, the first 8 days of methotrexate intravenously 120mg / M ~ 2,24 hours Use L-asparaginase. This 2-day regimen is repeated every 7 to 14 days. Methotrexate per treatment increased 40mg / M ~ 2, until not tolerated. L-asparaginase