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以6-氯-2-氯甲基-3-喹啉甲酸乙酯(1)为底物,在无水碳酸钾作为缚酸剂、乙腈作为溶剂、聚乙二醇-400作为相转移催化剂的条件下分别与水杨醛(2a~2i)、邻羟基苯乙酮(2j~2o)及2-羟基-1-萘醛(2p)经“三步一锅法”在超声辅助下回流反应,成功的合成了2-(2-苯(萘)并呋喃基)-6-氯-3-喹啉甲酸衍生物(3a~3p).所合成化合物的结构均通过红外光谱、核磁共振氢谱、核磁共振碳谱和高分辨质谱得以证实.
Using ethyl 6-chloro-2-chloromethyl-3-quinolinecarboxylate (1) as a substrate, anhydrous potassium carbonate as an acid scavenger, acetonitrile as a solvent and polyethylene glycol-400 as a phase transfer catalyst Under the conditions of salicylaldehyde (2a ~ 2i), o-hydroxyacetophenone (2j ~ 2o) and 2-hydroxy-1-naphthaldehyde (2p) by the "three-step one- (3a ~ 3p), 2- (2-benzene (naphthalene) furanyl) -6-chloro-3-quinolinecarboxylic acid derivatives were successfully synthesized.The structures of the synthesized compounds were confirmed by IR, 1H NMR Spectra, nuclear magnetic resonance (NMR) and high-resolution mass spectra were confirmed.