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雷公藤总苷是常用的免疫抑制剂,该药具有抑制免疫,抑制肾小球系膜细胞增殖,抑制炎症反应的作用,并且可以改善肾小球滤过膜的通透性,防止蛋白的丢失;然而雷公藤的副作用主要表现为性腺抑制,肝毒性和白细胞减少等,大大限制了临床的应用,文章通过探讨麒麟丸治疗雷公藤引起的生殖毒性的不良反应,为临床应用提供依据。
Tripterygium glycosides glycosides are commonly used immunosuppressive agents, the drug has the effect of inhibiting immunity, inhibiting the proliferation of mesangial cells and inhibiting the inflammatory reaction, and can improve the permeability of glomerular filtration membrane and prevent the loss of protein However, the side effects of Tripterygium wilfordii mainly manifested as gonadal suppression, hepatotoxicity and leukopenia, which greatly limits the clinical application. The article provides the basis for clinical application by investigating the adverse reaction of Kirin Pill in treating the reproductive toxicity caused by Tripterygium wilfordii.