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氨茶碱在国外近来推荐用于早产儿呼吸暂停、呼吸窘迫综合征等疾病,认为能降低窒息的发生,缩短插管日期和早期停用呼吸机,并根据血药浓度和药动学的参数进行了许多给药方案的研究。我国有关专家也提倡应用此药,但由于药物监测工作尚未普及,且无我国新生儿的药动学参数,限制了临床上的使用。为此,我院在9例新生儿中研究了静注给药前后的药代动力学,并结合对临床规常用前后监测的结果,对合理用药提出初步的建议。对象与方法
Aminophylline recently recommended for use in premature infants, apnea, respiratory distress syndrome and other diseases, that can reduce the incidence of asphyxia, shorten the intubation date and early disable ventilator, and based on plasma concentration and pharmacokinetic parameters Many dosing regimens have been studied. Relevant experts in our country also advocate the application of this medicine. However, as the drug monitoring work has not yet been popularized, and there are no pharmacokinetic parameters for newborn babies in our country, the clinical use is limited. To this end, our hospital in 9 cases of neonatal pharmacokinetics before and after intravenous administration study, combined with the clinical routine monitoring before and after the results of the rational use of drugs made preliminary recommendations. Objects and methods