本文报导英格兰东北部于1969年开始的一项协作研究,共有26例耐多种药物的慢性肺结核病人。全部病例均对链霉素、PAS和异烟肼无反应,大多数病例用乙硫异烟胺、吡嗪酰胺和环丝氨酸治疗无效。在医院或家庭的严密监督下给予乙氨丁醇(Ethambutol)和利福平(Rifampicin)治疗,每天给药一次。由于没有明显副作用,因此病人接受这种治疗无何困难。每月取3个痰标本作涂片或培养。治疗6个月后,26 This article reports a collaborative study that began in 1969 in northeastern England with a total of 26 patients with multiple drug-resistant chronic tuberculosis. All cases did not respond to streptomycin, PAS and isoniazid, and most of the cases were ineffective with ethionamide, pyrazinamide and cycloserine. Ethambutol and Rifampicin are administered on a daily basis under the close supervision of a hospital or home. Since there are no obvious side effects, there is no difficulty for the patient in receiving such treatment. Take 3 sputum specimens for smear or culture every month. After 6 months of treatment, 26