1988年Bumgardner等人率先提出了肝细胞移植概念,1993年Mito等在世界上开展了首例人体肝细胞移植。此后,从原位整肝移植到原位肝细胞移植,进而发展到干细胞移植,肝细胞移植治疗技术取得了巨大进展。特别是近年来随着肝干细胞分离、培养、鉴定及其增殖技术的发展和成熟,将多种来源的肝干细胞用作细胞移植、生物人(?)肝装置以及基因治疗的主要来源细胞,已经引起了广泛关注。 In 1988, Bumgardner and others pioneered the concept of liver cell transplantation. In 1993, Mito et al performed the first human hepatocyte transplantation in the world. Since then, from in situ liver transplantation to in situ hepatocyte transplantation, and then developed to stem cell transplantation, liver cell transplantation has made tremendous advances in treatment technology. Especially in recent years, with the development and maturation of hepatic stem cell isolation, culture, identification and proliferation techniques, various sources of hepatic stem cells have been used as the main source cells for cell transplantation, biological human liver devices and gene therapy. Aroused widespread concern.