论文部分内容阅读
近年胰腺癌的发病率呈逐年上升趋势,本病恶性程度较高,与其早期局部侵犯和转移有关,因此早期诊断胰腺癌是实施根治性切除、延长患者生存期的关键。目前临床上尚缺乏有效的非创伤性早期筛查手段,多数患者确诊时已不能行手术切除。随着近年分子生物学和高通量测序技术的发展,在全基因组、转录组、蛋白质组水平筛选胰腺癌分子标记物成为了可能,可有效提高本病的早期诊断率。本文就胰腺癌分子诊断的研究进展作一综述。
In recent years, the incidence of pancreatic cancer showed an upward trend year by year, the higher the degree of malignancy of the disease, and its early local invasion and metastasis, so early diagnosis of pancreatic cancer is the implementation of radical resection and prolong the survival of patients the key. At present, there is a lack of effective non-invasive early screening methods in clinical practice. Most of the patients can not have surgical resection at the time of diagnosis. With the development of molecular biology and high-throughput sequencing technology in recent years, it is possible to screen pancreatic cancer molecular markers at the whole genome, transcriptome and proteomics level, which can effectively improve the early diagnosis rate of this disease. This article reviews the progress of molecular diagnosis of pancreatic cancer.