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采用聚合酶链反应检测１００例慢性乙肝患者血清、唾液及尿液中ＨＢＶＤＮＡ结果：血清中ＨＢＶＤＮＡ阳性率最高，为８０％，显著高于唾液及尿液（Ｐ值均小于０．０１）。ＨＢｅＡｇ（＋）、抗－ＨＢｅ（－）组与ＨＢｅＡｇ（－）、抗－ＨＢｅ（＋）组比较，前者血清及唾液中ＨＢＶＤＮＡ检出率明显高于后者（Ｐ值分别小于０．０１和０．０５）。ＨＢｅＡｇ（＋）、抗－ＨＢｅ（－）组与其他模式组比较，前者只有血清中ＨＢＶＤＮＡ阳性显著高于后者（Ｐ＜０．０１），结果提示：①ＨＢＶＤＮＡ阳性率与ＨＢＶＭ存在状态密切相关。②评价乙肝患者是否存在ＨＢＶ复制及传染性，不能单纯依靠ＨＢＶＭ，二者互补检测将有助于提高乙肝诊断率及ＨＢＶ是否复制。
Serum, saliva and urine HBVDNA were detected by polymerase chain reaction in 100 patients with chronic hepatitis B. The highest positive rate of HBV DNA in serum was 80%, which was significantly higher than saliva and urine (P <0.01). The positive rates of HBVDNA in serum and saliva of HBeAg (+) and anti-HBe (-) group were significantly higher than those of HBeAg (-) and anti-HBe group 0.05). HBeAg (+), anti-HBe (-) group compared with the other model group, the former only HBVDNA serum was significantly higher than the latter (P <0.01), the results suggest: ① HBVDNA positive rate and HBVM exist closely related. ② evaluation of hepatitis B patients with HBV replication and contagious, can not simply rely on HBVM, the two complementary testing will help to improve the diagnosis of hepatitis B and HBV replication.