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目的：回顾性分析老龄男性对单精子卵泡浆内注射（ICSI）结果影响。方法将男性患者分成两组，平均年龄（64±3）岁以上为研究A组（27例），平均年龄（35±2）岁为对照B组（54例），该两组的女性配偶平均年龄相仿。结果两组之间的受精率无明显统计学差异（75.3%与82.4%），但B组的临床妊娠率要明显高于A组（P＜0.01），但仍需要更多研究。另外A组患者精液分析显示精液量、精子浓度、正常精子形态率均明显低于B组（P＜0.05），但这并不影响卵子的受精率。结论男性年龄会影响ICSI治疗后的临床妊娠率。“,”Objective To investigate the effects of advanced paternal age on intracytoplasmic sperm injection outcome. Methods There were two age groups of men in the study including Group A(n=27, with a mean age of 64± 3 years) and Group B(n=54, with a mean age of 35±2 years). The ages of female partners were matched between the two groups. Results: There was no significant difference in fertilization rate between the two groups (75.3 versus 82.4%). There was a significantly higher pregnancy rate in younger men group (P<0.01). However, the long-term outcome of these pregnancies needs further investigation. Semen analysis showed that semen volume,sperm concentration and sperm morphology in Group A than that in Group B (P<0.05), but these changes did not affect the fertilization rate. Conclusion:Advance paternal age might have an effect on the pregnancy rate after ICSI.