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目的:探讨术前介入化疗与放疗治疗Ⅰb-Ⅱa期巨块型宫颈癌的的近期疗效和价值。方法:对73例Ⅰb-Ⅱa期巨块型宫颈癌患者分组进行盆腔介入化疗与放疗,化疗组以卡铂300mg/m2、平阳霉素50mg/m2、长春新碱1mg/m2进行介入治疗;放疗组采用腔内后装治疗,每周一次,每次A点剂量6Gy～7Gy,A点总剂量20Gy～30Gy。经治疗后3周进行宫颈癌根治术。结果:术前介入治疗组比放疗组肿瘤退缩明显,总有效率(CR+PR)%分别为89.5%和71.4%,差异有显著性(P<0.05);介入化疗组与放疗组的淋巴结转移率分别为15.8%和17.1%,差异无显著性(P>0.05)。结论:Ⅰb-Ⅱa期巨块型宫颈癌患者术前行盆腔介入化疗近期疗效好于术前放疗者。
Objective: To investigate the short-term effect and value of preoperative interventional chemotherapy and radiotherapy in the treatment of stage Ⅰb-Ⅱa massive cervical cancer. Methods: Seventy-three patients with stage Ⅰb-Ⅱa massive cervical cancer underwent pelvic interventional chemotherapy and radiotherapy. The patients in the chemotherapy group were treated with carboplatin 300mg / m2, pingyangmycin 50mg / m2 and vincristine 1mg / m2. Radiotherapy Group using intracavity after treatment, once a week, each dose of A point 6Gy ~ 7Gy, A total dose of 20Gy ~ 30Gy. Three weeks after treatment of cervical cancer radical surgery. Results: Compared with the radiotherapy group, the tumor recanalization rate was significantly lower in the preoperative intervention group than in the radiotherapy group (89.5% vs 71.4%, respectively) (P <0.05). The rates of lymph node metastasis Rates were 15.8% and 17.1% respectively, with no significant difference (P> 0.05). Conclusion: The efficacy of preoperative pelvic interventional chemotherapy in stage Ⅰb-Ⅱa massive cervical cancer is better than that of preoperative radiotherapy.