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该研究主要观察含氟封闭剂的临床防龋效果，并将它同其它几种防龋方法进行比较。作者将上海市786名6～8岁儿童分成四组，分别作四种处理。它们是：含氟封闭剂、普通封闭剂、APFI凝胶、普通封闭剂加APFI凝胶。封闭剂在研究开始时使用于第一恒磨牙，APFI凝胶每半年使用一次。3年后观察这四种防龋方法对儿童牙齿的保护作用，结果显示；含氟封闭剂对受封闭牙面的防龋效果较普通封闭剂和APFI凝胶为高；对口腔中未封闭牙齿的保护作用也较普通封闭剂和APFI凝胶强；不同防龋措施对女学生的保护作用不如男学生。以上结果提示含氟封闭剂具有氟化物和封闭剂的双重作用，并能对周围未封闭牙齿起保护作用。
The main purpose of this study was to observe the clinical effect of fluoride-containing sealants on caries prevention and to compare it with several other caries-resistant methods. The author divides 786 6-8 year old children in Shanghai into four groups, each dealing with four kinds of treatment. They are: Fluorinated sealants, general sealants, APFI gels, and general sealants plus APFI gels. Blocking agents were applied to the first permanent molars at the start of the study, and APFI gels were used semi-annually. Three years later, we observed the protective effect of these four caries-preventing methods on children's teeth. The results showed that the anti-caries effect of fluoride-containing sealants on closed teeth was higher than that of ordinary sealers and APFI gels; Of the protective effect than the ordinary sealant and APFI gel; different anti-caries measures female students than the protective effect of male students. The above results suggest that the fluorine-containing sealant has the dual effect of fluoride and sealant and can protect the surrounding non-occluded teeth.