合成了4个系列共计28个具有不同配位模式的二氟或二氯苯甲酰异羟肟酸有机锡新化合物.分别为单核单配型[R2Sn(HL)2](a);单核异羟肟酸-羧酸混配型[R2Sn(HL)(R′COO)](b);一维多核型[R2SnL]n(c);四核芳基异羟肟酸-羟肟酸混配型[R4Sn2(HL)2(L)]2(d).以上4类新化合物均经元素分析,FT-IR,1HNMR,13CNMR和119SnNMR谱表征,部分通过X射线单晶衍射分析确证了结构.以顺铂对照,考察了以上28种新化合物对HL-60,Bel-7402,KB和BGC-823等4种瘤株的体外抗肿瘤活性,并对其构效关系进行了探讨. A total of 28 novel organotin compounds of difluoro or dichlorobenzoylhydroxamic acid with different coordination modes were synthesized in 4 series, which were single-core single-complex [R2Sn (HL) 2] (a) (R2Sn (HL) (R’COO)] (b); one-dimensional polynuclear type [R2SnL] n (c); tetranuclear aryl hydroxamic acid-hydroxamic acid The four new compounds were characterized by elemental analysis, FT-IR, 1HNMR, 13CNMR and 119SnNMR spectra, respectively, and confirmed by X-ray single crystal diffraction analysis The antitumor activities of the above 28 new compounds on four tumor cell lines, HL-60, Bel-7402, KB and BGC-823, were investigated in cisplatin control. The structure-activity relationship was also discussed.