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对照观察了自体混合HLA半相合异基因骨髓移植(MBMT)后,用rHG-CSF对造血功能重建的影响及相关临床表现,证明用rhG-CSF组白细胞>1.0×10~9/L、粒细胞>0.5×10~9/L的时间显著短,病人发生感染者少和轻,发热不高,时间较短,且减少全血和粒细胞成分的输入量,与未用rhG-CSF组比较形成明显对照。提示在MBMT后应用rhG-CSF可缩短患者的白细胞减少期,加速造血的重建,减少患者的感染和静脉抗菌素、全血和粒细胞的用量。
The effects of rHG-CSF on hematopoietic reconstitution after autologous mixed HLA haploidentical bone marrow transplantation (MBMT) and related clinical manifestations were observed. It was proved that the rhG-CSF group had leukocytes >1.0×10-9/L, granulocytes. >0.5x10~9/L was significantly shorter, the patient developed fewer and lighter infections, fever was not high, time was short, and the input of whole blood and granulocyte components was reduced, compared with the non-rhG-CSF group Obvious contrast. It is suggested that the application of rhG-CSF after MBMT can shorten the leucopenia of patients, accelerate the reconstruction of hematopoiesis, reduce the infection of patients and use of intravenous antibiotics, whole blood and granulocytes.