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华法令与许多药物有相互作用。国内有关资料在解释其相互作用原理时,大都归于与血浆蛋白结合的置换和肝药酶诱导剂能促进该类药物的代谢所致,但是忽略了药物与华法令相互作用的另一主要原因。以后的研究证明一些药物如保泰松、甲氰咪胍、甲硝唑、复方新诺明和硫氮唑酮等与华法令的相互作用呈立体选择性,华法令分子有两种不同旋光体-左旋华法令和右旋华法令,在与华法令这两个旋光体发生相互作用过程中,甲硝唑、复方新诺明、保泰松、硫氮唑酮等主要抑制左旋华法令的氧化代谢;甲氰咪胍则主要抑制右旋华法令的氧化代谢;而保泰松则可能诱导右旋华法令的氧化代谢.
Warfarin interacts with many drugs. Relevant domestic data to explain the principle of interaction, mostly associated with the plasma protein-binding and liver drug inducer can promote the metabolism of such drugs, but ignored the drug interacting with warfarin another major reason. Subsequent studies have demonstrated the stereoselectivity of some drugs such as phenylbutazone, cimetidine, metronidazole, cotrimoxazole and thiazide and warfarin, and warfarin has two different polarimeters - L-warfarin and dextrose warfarin, metronidazole, cotrimoxazole, phenylbutazone, and thiazolidone inhibit the oxidative metabolism of L-warfarin during their interaction with warfarin ; Cimetidine mainly inhibits dextrose and warfarin oxidation metabolism; and phenylbutazone may induce dextrose and warfarin oxidative metabolism.