胃复安是一种多巴胺受体阻断剂,能抑制延髓催吐化学感受区多巴胺受体,有较强的止吐效能,1964年France首先用于临床。1965年Borenstein和Bles报道大剂量胃复安可致锥体外系反应,1968年Witzel发现正常范围的剂量也可产生本症。近20余年来,国内亦有大量关于胃复安副作用的报道。 Metoclopramide is a dopamine receptor blocker that inhibits dopaminergic receptors in the medullary emetic chemosensory zone and has strong antiemetic properties. France was first used clinically in 1964. Borenstein and Bles in 1965 reported that large doses of metoclopramide can cause extrapyramidal reactions, 1918 Witzel found that the normal range of doses can also cause this disease. Nearly 20 years, there are a lot of domestic reports on the side effects of metoclopramide.