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肺癌是造成我国居民死亡的主要原因,常规抗肿瘤药物副作用大、易产生耐药性[1]。中药单体及其有效成分通过大量实验研究证实可以干预肿瘤的生长和转移、影响细胞周期与细胞凋亡、抑制肿瘤血管再生、减少相关细胞因子分泌,甚至调控肿瘤细胞自噬,具有多靶点优势。本文对目前中药单体及其有效成分治疗Lewis肺癌的实验研究现状做一总结,并对目前存在的问题进行思考。1中药单体及其有效成分1.1亚麻木酚紊(SDG)亚麻木酚素是亚麻籽中提取出的有效成分[2]。中药亚麻籽具有养血祛风润燥、调节血脂的功效。有研究发现,肺癌的发生可能与性别激素有关D叫’。而SDG在肠道微生物
Lung cancer is the main cause of death of our residents, conventional antitumor drugs side effects, easy to produce resistance [1]. Chinese medicine monomer and its active ingredients through a large number of experimental studies have shown that it can intervene in tumor growth and metastasis, affecting cell cycle and apoptosis, inhibit tumor angiogenesis, reduce the secretion of related cytokines, and even regulate tumor cell autophagy, with multiple targets Advantage. This article summarizes the current experimental research status of Chinese herbal medicine and its active ingredients for the treatment of Lewis lung cancer, and ponders over the existing problems. 1 Chinese medicine monomer and its active ingredient 1.1 Flaxenol (SDG) Flax lignans are the active ingredients extracted from flaxseed [2]. Flaxseed with traditional Chinese medicine Qufengchunan nourishing, regulating the effectiveness of blood lipids. Some studies have found that the occurrence of lung cancer may be related to sex hormones D ’. While SDG is in the gut microbiota