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目的评估呼出气一氧化氮(FeNO)检测在慢性咳嗽患者病因诊断及预测激素治疗敏感性中的应用价值。方法收集2012年1—12月慢性咳嗽患者60例,予以FeNO检测、支气管舒张或激发试验,并吸入激素2周后复查FeNO。对于诊断不明患者行进一步检查,明确病因。结果咳嗽变应性哮喘(CVA)、嗜酸粒细胞性支气管炎(EB)组FeNO明显高于其他组。该二组患者应用激素后患者症状得到缓解,复查呼出气一氧化氮数值均有明显下降(P<0.05)。支气管舒张或激发试验阳性患者呼出气一氧化氮明显高于阴性患者。结论 FeNO作为一种气道炎症标志物在不明原因慢性咳嗽的病因诊断和鉴别方面及预测激素的有效性方面有一定的应用价值。
Objective To evaluate the diagnostic value of exhaled nitric oxide (FeNO) in the etiological diagnosis of chronic cough and the prediction of the sensitivity of hormone therapy. Methods Sixty patients with chronic cough from January to December in 2012 were enrolled. FeNO, bronchial dilation or provocation test were performed. For patients with unknown diagnosis to further examination, a clear cause. Results FeNO in cough allergic asthma (CVA) and eosinophilic bronchitis (EB) were significantly higher than those in other groups. The symptoms of the two groups were relieved after the application of hormones, and the values of exhaled nitric oxide were significantly decreased (P <0.05). Bronchial diastolic or provocation test positive patients with exhaled nitric oxide was significantly higher than negative patients. Conclusion FeNO as a marker of airway inflammation has certain value in the diagnosis and identification of the etiology of chronic cough of unknown origin and in predicting the effectiveness of the hormone.