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对四个地区911名CS_2作业男工调查结果,其子代出生缺陷和其妻子自然流产的发生率分别达20.82％和5.97％,均显著高于对照组,其发生率的高低与接触CS_2浓度的高低有一定剂量反应关系。对接触GS_2的平均浓度为35mg/m~3的男工调查结果,性功能减退、精子形态异常、精子活动率低下、精子数少的发生率均显著高于对照组。小鼠吸入10mg/m~3或100mg/m~3的CS_2 5周、睾丸的初级精母细胞常染色体畸变率和性染色体异常率及精子畸变率均显著增高。以上表明CS_2能损伤男性生殖功能,对雄性小鼠生殖细胞有致突变效应,并对男工和雄性小鼠的精子生成有毒害作用。
The survey results of 911 male CS_2 workers in four districts showed that the incidence of birth defects and spontaneous abortion of their wives were 20.82% and 5.97% respectively, which were significantly higher than those of the control group. The incidence of CS_2 and CS_2 The level of a certain dose-response relationship. The results of male workers who were exposed to GS_2 with an average concentration of 35 mg / m ~ 3 were significantly higher than those of the control group. The incidence of sexual dysfunction, abnormal sperm morphology, low sperm motility, and low sperm count were all significantly higher. Mice inhaled 10mg / m ~ 3 or 100mg / m ~ 3 of CS_2 for 5 weeks, primary spermatocytes in testis atherosclerosis rate and sex chromosome abnormality rate and sperm aberration rate were significantly increased. These results indicated that CS_2 could injure male reproductive function, cause mutagenic effects on germ cells of male mice, and cause toxic effects on male workers and male mice.