基因系统根据编码分子的分布与功能不同,将人类白细胞抗原(human leukocyte antigen,HLA)分为Ⅰ、Ⅱ、Ⅲ3大类,HLA-DQB1属于Ⅱ类基因。HLAA、B、DRB1基因是早期研究的与造血干细胞移植密切相关的3个功能基因。随着研究的不断深入和方法的更新,HLA-DQB1基因在造血干细胞移植中也日益受到重视~([1])。目前,国外造血干细胞移植均对供患进行HLA-DQB1高分辨基因配型。我们对岳阳地 According to the distribution and function of the coding molecules, the gene system divides human leukocyte antigen (HLA) into categories I, II and III, and HLA-DQB1 belongs to class II genes. The HLAA, B and DRB1 genes were three functional genes closely related to hematopoietic stem cell transplantation. With the deepening of research and updating of methods, HLA-DQB1 gene is also increasingly valued in hematopoietic stem cell transplantation ([1]). At present, foreign hematopoietic stem cell transplantation for HLA-DQB1 for high-resolution genotyping. We Yueyang