目的分析浙江省2004-2006年沿海地区伤寒副伤寒流行趋势,为制定伤寒副伤寒防控措施提供依据。方法将浙江省沿海地区近三年伤寒副伤寒报告病例和监测点监测报表资料录入EXCEL2003整理后用SPSS12.0统计软件进行统计分析。结果沿海地区伤寒副伤寒呈下降趋势,发病曲线由双峰型变为单峰型,且峰值逐年降低。病例在宁波和温州以农民、工人、学生为主,台州地区以民工、农民、学生为主,病例年龄集中在20～50岁,男性略多于女性。疑似病例和临床诊断病例阳性率没有明显差别,恢复期患者带菌率显著高于健康从业人员,病原菌以甲型副伤寒沙门菌为主,甲型副伤寒对利福平和萘啶酸耐药,且耐药率在97%以上。暴发疫情以水型为主。结论浙江省沿海地区伤寒副伤寒发病总体呈发病率逐年下降的趋势,但甲型副伤寒的发病呈上升趋势,对病例应规范治疗彻底治愈、加强恢复期患者的监测,发现阳性应及时隔离治疗,有利于疫情的控制。 Objective To analyze the epidemic trend of typhoid and paratyphoid in the coastal areas of Zhejiang Province from 2004 to 2006, and provide the basis for prevention and control measures of typhoid and paratyphoid fever. Methods The case reports and monitoring reports of typhoid and paratyphoid fever in the coastal areas of Zhejiang Province for the past three years were collected and recorded in EXCEL2003 and analyzed with SPSS12.0 statistical software. Results The typhoid and paratyphoid fever in coastal areas showed a decreasing trend. The onset curve changed from bimodal to unimodal, and the peak decreased year by year. The cases were mainly farmers, workers and students in Ningbo and Wenzhou. Among them were migrant workers, peasants and students in Taizhou area. The cases were mainly from 20 to 50 years old and slightly more than men. There was no significant difference between the positive cases and the positive cases in the clinical diagnosis. The recovery rate of patients was significantly higher than that of health workers. The pathogen was mainly Salmonella paratyphi A. Paratyphoid A was resistant to rifampicin and nalidixic acid Resistance rate of 97% or more. The main outbreak of water-based epidemic. Conclusion The morbidity of typhoid and paratyphoid fever in the coastal areas of Zhejiang Province shows a decreasing trend year by year. However, the incidence of paratyphoid fever is on the rise. The cases should be completely cured by standardized treatment and the monitoring of convalescent patients should be strengthened. , Is conducive to the control of the epidemic.