含有C(sp3)—P键的有机磷化合物被广泛应用于有机合成、生物有机和药物化学、农药、阻燃剂和萃取剂等领域中.近年来,C—H键的直接磷酰化受到了广泛关注,该策略在构建C—P键中显示出更为简洁、高效和原子经济性等优势.综述了自2009年以来以仲膦氧化物和亚磷酸酯为磷源的C(sp3)—H磷酰化反应的研究进展,根据C(sp3)—H键的类型,对磷酰化反应分为五类进行介绍.“,”Organophosphorus compounds bearing C(sp3)—P bonds have been widely used in organic synthesis,bioorganic and medical chemistry,agrochemicals,flame retardants and extractants.In recent years,the direct phosphorylation of C—H bonds has received much attention because this strategy represents more straightforward,efficient and atom-economic construction of C—P bonds.The recent advances in C(sp3)—H phosphorylation using secondary phosphine oxides and phosphite esters as phosphorus sources since 2009 are reviewed,and the corresponding reactions are categorized in five types according to the structure of C(sp3)—H bonds.