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目的 :探讨多发性骨髓瘤 (MM )患者血清单克隆免疫球蛋白 (M 蛋白 )及IgG亚类的分布。 方法 :用免疫固定电泳对 2 36例MM患者血清中M 蛋白进行免疫球蛋白重链及轻链定性分析 ,并用单扩散法对其中 76例IgG型MM进行IgG亚类分析。 结果 :2 36例中 ,IgG型 10 4例 (44 .0 7% ) ,IgA型 6 0例 (2 5 .42 % ) ,IgD型 2 2例 (9.32 % ) ,轻链型 47例 (19.92 % ) ,未分泌型 3例 (1.2 7% )。对其中 76例IgG型MM研究发现 :IgG16 1例(80 .2 6 % ) ,IgG2 6例 (7.89% ) ,IgG1 IgG2 双克隆 1例 (1.32 % ) ,IgG38例 (10 .5 3 % ) ,未见IgG4 。结论 :血清M 蛋白重链及轻链分类及IgG亚类的检测对MM的免疫分型、指导临床治疗及判断疾病预后具有一定的意义
Objective: To investigate the distribution of serum monoclonal immunoglobulin (M protein) and IgG subclasses in patients with multiple myeloma (MM). METHODS: Immunoglobulin heavy chain and light chain were qualitatively analyzed by immunofixation electrophoresis on the M protein in serum of 236 patients with MM. IgG subclasses of 76 IgG MM were analyzed by single diffusion method. RESULTS: Of the 36 cases, 104 were IgG (104.7%), 60 were IgA (24.42%), 22 were IgD (9.32%), 47 were light chain (19.92). %), 3 cases without secretory type (1.2 7%). Of these, 76 cases of IgG MM were found: IgG16 (80.6%), IgG2 (7.89%), IgG1 IgG2 double (1.32%), and IgG (10.53%). No IgG4 was seen. Conclusion : The classification of heavy chain and light chain of serum M protein and the detection of IgG subclasses have certain significance for immunophenotyping of MM, guiding clinical treatment and judging disease prognosis.