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大环内酯类抗生素的心脏毒性主要表现为QT间期延长和尖端扭转型室性心动过速,临床上可出现昏迷和猝死,以红霉素诱发为多,这是大环内酯类抗生素的一种特殊类型的不良反应。其发生机制是延长心肌动作电位时间,诱发心脏浦肯野纤维的早期后除极。为减少或避免心脏毒性的发生,临床医师在应用本类药物前需了解其诱发心脏毒性的可能性,根据患者病情和合用药物情况谨慎选药,用药期间注意观察,必要时监测心电图,一旦发生心脏毒性应采取积极治疗措施。
Cardiac toxicity of macrolide antibiotics mainly for the QT prolongation and torsades de pointes tachycardia, clinical coma and sudden death can be induced by erythromycin, which is macrolide antibiotics A special type of adverse reaction. Its mechanism is to extend the action potential of myocardial time, inducing Purkinje fiber heart after the early post-depolarization. In order to reduce or avoid the occurrence of cardiotoxicity, clinicians should know the possibility of cardiotoxicity before using this class of drugs, carefully select drugs according to patient’s condition and combined drugs, observe the observation during the medication, monitor the ECG if necessary, Cardiac toxicity should take aggressive treatment.