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目的研究血浆D-二聚体检测对肺癌的诊断价值及预后指导意义。方法取87例肺癌患者和60例对照组健康查体人员的静脉血，采用乳胶凝集法检测血浆D－M聚体。结果87例肺癌患者68例呈阳性反应，阳性率为78．16％，对照组均呈阴性反应，两组比较有显著性差异（P＜0．001）。按TNM分期D-二聚体检测结果，Ⅲ期46例中41例呈阳性反应，Ⅳ期21例全部呈阳性反应，二者与Ⅱ期比较，有显著性差异（P＜0．001）。伴有转移者占73．56％，均呈阳性反应。结论肺癌患者具有凝血活性亢进和继发性纤溶亢进。按TNM分期，D-二聚体随病情加重而升高，与预后显著相关。该方法迅速、简便、敏感性高,可作为肺癌辅助诊断与预后判断的一项早期诊断标准.
Objective To study the diagnostic value of plasma D-dimer in lung cancer and its prognostic significance. Methods The venous blood of healthy examinees in 87 patients with lung cancer and 60 controls was measured. The plasma D-M aggregate was detected by latex agglutination. Results Of 87 patients with lung cancer, 68 were positive and the positive rate was 78.16%. The control group showed a negative reaction. There was a significant difference between the two groups (P<0.001). According to the results of TNM staging D-dimer assay, 41 of 46 patients in stage III were positive and 21 patients in stage IV were all positive. There was a significant difference between the two groups compared with stage II (P<0.001). 73.56% of the patients with metastasis were positive. Conclusion Lung cancer patients have hypercoagulability and secondary hyperfibrinolysis. According to TNM staging, D-dimer increased with worsening of the disease, which was significantly associated with prognosis. The method is rapid, simple, and highly sensitive. It can be used as an early diagnostic criteria for the diagnosis and prognosis of lung cancer.