卡介苗系由法国细菌学家卡(Calmcette)、介(Guerin)二氏首先制成,故以此命名。卡氏等把烈性牛型结核菌培养在含牛胆汁的培养基内,经多年反复移植后,病菌的毒性已大大减弱。注射人体,不现病状,但能引起免疫作用,其预防结核传染约有80％的效果。以往一直把卡介苗作为特异性预防结核病的疫苗来加以使用。近年来,通过大量动物实验及临床实验材料证明卡介苗尚有非特异性作用,而能抵抗其他细菌、病毒 The BCG was first made by the French bacteriologist Calmcette and Guerin II and was named after it. KG et al. cultured virulent bovine tuberculosis bacteria in a medium containing bovine bile. After repeated transplantations for many years, the toxicity of the bacteria has been greatly reduced. Injecting the human body does not present a pathological condition, but it can cause an immune effect, and its prevention of tuberculosis infection has an effect of about 80%. BCG has been used as a vaccine against tuberculosis in the past. In recent years, a large number of animal experiments and clinical experimental materials have proven that BCG has non-specific effects and can resist other bacteria and viruses.