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【目的】探讨不同剂量奥美拉唑治疗非静脉曲张上消化道出血的疗效。【方法】选取2012年6月至2013年7月本院收治的128例非静脉曲张上消化道出血患者，随机分为观察组和对照组各64例，观察组给予大剂量奥美拉唑治疗，对照组给予常规剂量奥美拉唑治疗，比较两组患者的临床疗效并记录分析两组患者治疗前后各观察指标的变化，并于治疗72 h后评估两组患者的胃内 pH 值及不良反应发生情况。【结果】观察组临床疗效优于对照组（P＜0．05）；观测指标改善情况、胃内 pH 值及不良反应发生情况两组间无显著性差异（P＞0．05）。【结论】大剂量奥美拉唑治疗非静脉曲张上消化道出血有良好的临床疗效。“,”[Objective]To explore compare the efficacy of different doses of omeprazole for the treatment of non-varicose upper gastrointestinal hemorrhage.[Methods]Totally 128 patients with non-varicose upper gastrointestinal hemorrhage in our hospital were chosen from June 2012 to July 2013.According to random in-formed consent principle,all patients were divided into treatment group and control group with 64 patients in each group.The treatment group was given large dose of omeprazole,while the control group was given nor-mal dose of omeprazole.Clinical efficacy was compared between two groups.The changes of each index of two groups before and after treatment were recorded and analyzed.Intragastric PH and the incidence of adverse re-actions in two groups were evaluated 74h after treatment.[Results]Clinical efficacy of treatment group was better than control group(P0.05).[Conclusion]Large dose of omeprazole has good clinical efficacy in treating non-varicose upper gastrointestinal hemorrhage.