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目前认为病毒性肝炎的发病与机体的免疫应答及免疫调节功能紊乱有关。日本学者Muto及国内学者张定风、孙永良等检测了各型肝炎病人血浆中肿瘤坏死因子(TNF)活性,认为TNF与急性重症肝炎的发病机理有关。为进一步探讨TNF在慢性病毒性肝病发病过程中的作用,我们检测了慢性活动型肝炎、慢性重症肝炎及活动性肝炎后肝硬变患者血浆中TNF活性,并同时检测了急性黄疸型肝炎及正常人作对照。
At present, the incidence of viral hepatitis is related to the body’s immune response and immune dysfunction. Japanese scholar Muto and Chinese scholar Zhang Dingfeng and Sun Yongliang examined the activity of tumor necrosis factor (TNF) in plasma of various types of hepatitis patients, and found that TNF is related to the pathogenesis of acute severe hepatitis. To further explore the role of TNF in the pathogenesis of chronic viral liver disease, we tested the TNF activity in plasma of patients with chronic active hepatitis, chronic severe hepatitis and active cirrhosis and detected acute jaundice hepatitis and normal people As a control.