胰腺癌是美国目前第五大与癌症有关的死亡原因之一，其5年生存率不超过3％。早期胰腺癌或它的前期病变并没有显著的特征，而且靠目前的方法也难以发现。实验模型被证明是研究胰腺癌的最佳方法，然而目前的胰腺癌实验模型或者是不能复制导管表现型，或者是同时引起了其它器官的 Pancreatic cancer is currently the fifth leading cause of cancer-related death in the United States, with a 5-year survival of no more than 3%. Early pancreatic cancer or its precancerous lesions and no significant features, but also by the current method is difficult to find. Experimental models have proven to be the best way to study pancreatic cancer. However, current experimental models of pancreatic cancer either fail to replicate the ductal phenotype or cause both other organs