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目的比较大鼠三种不同脊柱融合模型的优越性及融合率。方法 60只SD大鼠随机分成三组,分别行椎体间(有内固定)、后外侧路(横突间)、椎体间(无内固定)三种不同术式的脊柱融合,3周、6周后进行手法触诊、X线评价、组织学观察,对三种融合模型进行分析。结果 3周时椎体间(有内固定)融合组、横突间融合组和椎体间(无内固定)融合组均未出现融合;6周时椎体间(有内固定)融合率为40%、横突间融合率为40%、椎体间(无内固定)融合率为20%。结论椎体间(有内固定)及后外侧路(横突间)融合均有良好的植骨床,局部相对稳定,手术相对简单易行,且术后并发症少,是骨替代材料等等具有成骨性或骨诱导性的移植物或药物能否提高脊柱融合率适用的一种动物融合模型。
Objective To compare the superiority and fusion rate of three different spinal fusion models in rats. Methods Sixty Sprague-Dawley rats were randomly divided into three groups. Three different types of spinal fusion were performed between the intervertebral body (with internal fixation), posterior lateral approach (lateral process), and intervertebral body (without internal fixation) Six weeks later, palpation, X-ray examination and histological observation were performed to analyze the three fusion models. Results No fusion occurred between the interbody fusion group, the interbody fusion group and the interbody fusion group at 3 weeks. At 6 weeks, the interbody fusion rate was 40%, 40% fusion rate between the transverse process, interbody (no internal fixation) fusion rate of 20%. Conclusion The fusion between the intervertebral body (with internal fixation) and posterior lateral approach (transverse process) has a good bone graft bed, the local relative stability, relatively simple operation, and less postoperative complications, is a bone substitute material and so on An animal model of fusion with osteogenic or osteoinductive grafts or drugs that improves spinal fusion rates.