胰岛素类似物(insulinsimilitude)是一类通过肽链修饰,在分子结构、生物活性、免疫原性与人胰岛素相似的生物合成制剂,可分为二类:(1)短效胰岛素类似物:赖脯胰岛素和门冬胰岛素,能模拟生理性餐时胰岛素分泌模式;(2)长效胰岛素类似物:甘精胰岛素和地特胰岛素,能模拟生理性基础胰岛素分泌模式。地特胰岛素(insulin detemir)属于新一代长效胰岛素类似物,笔者就其最新临床研究进展综述如下。 Insulinsimilitude is a class of biosynthetic agents that are similar in structure, biological activity and immunogenicity to human insulin by peptide chain modification. They are divided into two groups: (1) short-acting insulin analogs: Insulin and aspart insulin, can simulate the physiological pattern of insulin secretion; (2) long-acting insulin analogues: glargine and insulin special insulin, can simulate the physiological basis of insulin secretion patterns. Insulin insulin (insulin detemir) belong to a new generation of long-acting insulin analogues, the author of its latest clinical research progress are summarized below.