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特发性血小板减少性紫癜(ITP)是一种自身免疫性疾病,是临床最常见的出血性疾病,其发病机制目前仍未完全明确。慢性ITP病情易反复,部分难治性ITP预后差。近年来,对ITP发病机制的研究取得了一系列重要进展。在体液免疫机制方面,对自身抗体产生的研究有了明显进展,并提出了由自身抗体介导引起的巨核细胞数量和质量异常;在细胞免疫机制方面,除了共刺激信号理论和Th细胞失衡及一系列细胞因子异常外,又提出了调节性T细胞数量减少及细胞毒T细胞直接溶解血小板的新理论。现就ITP发病机制的研究进展作一综述。
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease, is the most common clinical bleeding disorder, the pathogenesis is still not completely clear. Chronic ITP easy to repeat the disease, some refractory ITP poor prognosis. In recent years, research on the pathogenesis of ITP has made a series of important progress. In the mechanism of humoral immunity, the research on autoantibodies has made significant progress, and the quantity and quality abnormalities of megakaryocytes caused by autoantibodies have been proposed. In addition to the co-stimulatory signal theory and Th cell imbalance, In addition to a series of cytokine abnormalities, a new theory of reducing the number of regulatory T cells and directly lysing the platelets by cytotoxic T cells was proposed. Now ITP pathogenesis research progress is reviewed.