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目的:探讨青蒿素对小鼠移植乳腺癌MT40作用及CD71表达。方法:建立MT40荷瘤小鼠模型,分为阴性对照组、青蒿素实验组、阳性对照组,测量各组肿瘤体积、制作生长曲线、检测各组肿瘤组织细胞凋亡率及CD71的表达率。结果:与阴性对照组相比,青蒿素实验组、阳性对照组荷瘤鼠肿瘤生长均受到抑制,青蒿素实验组与阳性对照组比较,t=1.423,P>0.05,青蒿素实验组与阴性对照组比较,t=3.437,P<0.05,有统计学意义;青蒿素实验组细胞凋亡率为21.23%,阳性对照组凋亡率为17.42%,青蒿素实验组与阴性对照组相比,t=8.193,P<0.05,有统计学意义,青蒿素实验组与阳性对照组相比,t=1.140,P>0.05,没有统计学意义;阴性对照组CD71表达阳性率77.81%,阳性对照组CD71表达阳性率70.42%,青蒿素实验组CD71表达阳性率40.23%,青蒿素实验组与阴性对照组相比,t=7.371,P<0.05,有统计学意义,青蒿素实验组与阳性对照组相比,t=5.338,P<0.05,有统计学意义。结论:青蒿素对小鼠移植乳腺癌MT40具有显著抑制生长、诱导细胞凋亡作用,并可以降低肿瘤组织CD71表达,可能通过下调肿瘤组织CD71的表达致抑制肿瘤生长、诱导细胞凋亡作用。
Objective: To investigate the effect of artemisinin on the transplanted breast cancer MT40 and the expression of CD71 in mice. Methods: MT40 tumor-bearing mice model was established and divided into negative control group, artemisinin experimental group and positive control group. The tumor volume of each group was measured and the growth curve was made. The apoptosis rate of tumor cells and the expression of CD71 . Results: Compared with the negative control group, the growth of tumor-bearing mice in artemisinin-treated group and positive control group were all inhibited. Compared with the positive control group, the artemisinin-treated group showed t = 1.423, P> 0.05, Compared with the negative control group, t = 3.437, P <0.05, statistically significant; artemisinin experimental group apoptosis rate was 21.23%, the positive control group apoptosis rate was 17.42%, artemisinin experimental group and negative Compared with the control group, t = 8.193, P <0.05, statistically significant, artemisinin experimental group compared with the positive control group, t = 1.140, P> 0.05, no statistically significant; negative control group, the positive rate of CD71 77.81%, positive rate of CD71 in positive control group was 70.42%, positive rate of CD71 in artemisinin experimental group was 40.23%, t = 7.371, P <0.05, compared with negative control group, Artemisinin experimental group compared with the positive control group, t = 5.338, P <0.05, statistically significant. CONCLUSION: Artemisinin can significantly inhibit the growth and induce apoptosis of mouse mammary carcinoma MT40 and reduce the expression of CD71. It may inhibit tumor growth and induce apoptosis by down-regulating the expression of CD71.