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至目前为止,根据中外文献尚未有痢疾桿菌引起小动物实验感染的记载,而在自然条件下,就目前所知,亦只能引起人与猴子发病。因而在研究痢疾发病及治疗的机转时,就产生了一定的困难。1955年匈牙利学者,1957年苏联微生物学者们及1958年冯振南等都曾引起了豚鼠的实验性痢疾角结膜炎;他们以此为模型,研究了抗菌素对于在机体内的痢疾桿菌的作用,以及其免疫机制等。1958年我们也曾成功地制成了痢疾性仓鼠的结膜炎。但仅以动物的结膜炎症变化进
So far, according to Chinese and foreign literatures, there is no record of experimental infection caused by dysentery bacillus in small animals. However, under natural conditions, as far as we know, it can only cause disease in humans and monkeys. Therefore, in the study of the pathogenesis and treatment of dysentery, it has produced some difficulties. Hungarian scholars in 1955, Soviet microbiologists in 1957 and Feng Zhennan in 1958 all caused experimental dysentery conjunctivitis in guinea pigs. They used this model to study the effect of antibiotics on Shigella in the body, Immune mechanism and so on. In 1958 we also successfully made conjunctivitis in dysentery hamsters. But only the animal’s conjunctivitis changes into