嘧啶类在生物体内新合成过程早被了解清楚,首先在乳酸桿菌中发现氨基甲酰磷酸是构成核糖核酸的嘧啶类前身物、往后参与该作用的氨基甲酰磷酸—天门冬氨酸转甲酰酶分别在大白鼠器官,鸽肝、大肠桿菌和人类红血球提出液中找到。二氢尿嘧啶甲酸酶则最早在尿嘧啶甲酸菌和棒状桿菌中找到,至于嘧啶的生物合成在癌细胞亦早已引起注意。核酸衍生物合成过程中返馈性的节制曾有不少报导,本文主要是观察代谢物和抗代谢物 Pyrimidines in the body of the new synthesis process is already well understood, first in Lactobacilli found carbamoyl phosphate is the pyrimidine precursor of ribonucleic acid, later involved in the role of carbamoyl-aspartic acid armor The acylases were found in the organs of rat, pigeon liver, E. coli and human erythrocytes respectively. Dihydrouracil formate is the earliest found in uracil formate bacteria and coryneform bacteria, as the pyrimidine biosynthesis in cancer cells has long drawn attention. There have been many reports on the feedback control during the synthesis of nucleic acid derivatives. This article mainly focuses on the observation of metabolites and antimetabolites