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目的：探讨喉癌浸润转移与纤维结合蛋白（Fibronectin，FN）的关系。方法：采用琼脂糖单向扩散和免疫酶染色（ABC法）检测喉癌病人血清及喉疾组织中FN的含量及表达。结果：喉疾病人血清中FN含量明显低于对照组，P＜0．01，喉癌组织中FN表达于细胞基质中，少部分表达于细胞膜上。结论：喉癌病人血清及组织中FN含量和表达下降与喉癌转移有关。
Objective: To investigate the relationship between invasion and metastasis of laryngeal carcinoma and fibronectin (FN). Methods: The content and expression of FN in serum and laryngopharyngeal tissues of patients with laryngeal cancer were detected by agarose one-way diffusion and immunoenzyme staining (ABC method). Results: The content of FN in serum of laryngeal patients was significantly lower than that of control group (P <0.01). The expression of FN in laryngeal carcinoma was in the stroma of cells, and the expression of FN in laryngeal carcinoma was less on the cell membrane. Conclusion: The decrease of FN content and expression in the serum and tissues of patients with laryngeal cancer is related to the metastasis of laryngeal carcinoma.