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【目的】观察山莨菪碱联合甲氰咪胍治疗过敏性紫癜的疗效,为临床诊治提供参考依据。【方法】将60例过敏性紫癜患儿随机分为两组:对照组30例,给予扑尔敏、糖皮质激素、维生素C、潘生丁等治疗;观察组30例,在对照组基础上加用山莨菪碱联合甲氰咪胍治疗。观察两组患儿用药后症状、体征变化。【结果】观察组总有效率为93.3%,对照组总有效率73.3%,二者比较差异有显著性(P<0.05)。观察组各型症状、体征消失时间与对照组比较,差异有显著性(P<0.05)。【结论】山莨菪碱联合甲氰咪胍治疗过敏性紫癜,有利于皮肤紫癜消退,改善皮肤型、腹型、关节型、肾型症状、体征,提高疗效。
【Objective】 To observe the curative effect of anisodamine combined with cimetidine in the treatment of Henoch-Schonlein purpura and to provide a reference for clinical diagnosis and treatment. 【Methods】 Sixty children with Henoch-Schonlein purpura were randomly divided into two groups: control group (n = 30), chlorpheniramine, corticosteroid, vitamin C and dipyridamole; the observation group (n = 30) Anisodamine combined with cimetidine. After treatment, the symptoms and signs of the two groups were observed. 【Results】 The total effective rate was 93.3% in the observation group and 73.3% in the control group. There was significant difference between the two groups (P <0.05). The observation group of various types of symptoms and signs disappeared compared with the control group, the difference was significant (P <0.05). 【Conclusion】 Anisodamine combined with cimetidine in the treatment of Henoch-Schonlein purpura is good for the skin purpura to regress and improve the skin type, abdominal type, joint type and renal type symptoms and signs, and improve the curative effect.