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目的:对淫羊藿苷隐形固体脂质纳米粒的冻干工艺进行优化并考察了其理化性质。方法:以冻干粉末的外观、色泽和再分散性为指标综合评价,优选处方比例;通过测定粒径、外观形态和体外释放度,对比了淫羊藿苷隐形固体脂质纳米粒冻干前后理化性质的变化。结果:制得的淫羊藿苷隐形固体脂质纳米粒冻干粉包封率为(74.00±1.45)%,载药量为(2.95±1.12)%,平均粒径(359.53±6.71)nm,Zeta电位-(33.79±2.96)mV;在生理盐水中,淫羊藿苷隐形固体脂质纳米粒冻干粉16 h累积释放37.48%。结论:优化处方制得隐形固体脂质纳米粒冻干粉具有较高包封率和载药量,体外释药符合Higuchi方程。
OBJECTIVE: To optimize the lyophilization process of icariin stealth solid lipid nanoparticles and investigate its physico-chemical properties. Methods: The appearance, color and redispersibility of freeze-dried powder were evaluated comprehensively and the prescription ratio was optimized. The particle size, appearance and in vitro release were compared to evaluate the effect of icariin stealth solid lipid nanoparticles Physical and chemical changes. Results: The encapsulation efficiency of Icariin stealth solid lipid nanoparticles was (74.00 ± 1.45)%, drug loading was (2.95 ± 1.12)%, average particle size was (359.53 ± 6.71) nm, Zeta potential - (33.79 ± 2.96) mV; In saline, icariin stealth solid lipid nanoparticles freeze-dried powder cumulative release of 37.48% 16 h. Conclusion: The optimized preparation of stealth solid lipid nanoparticles freeze-dried powder with high entrapment efficiency and drug loading, in vitro release in line with Higuchi equation.