论文部分内容阅读
目的 观察长期应用妥泰治疗癫痫的临床疗效、不良反应。方法 118例癫痫患者分为加用妥泰组和妥泰单药治疗组 ,观察时间为 6～ 2 7个月 ,平均 12 .7个月。结果 妥泰对各型癫痫治疗的总有效率为 82 .1% ,其中全身强直 阵挛性发作 (GTCS)总有效率为 83.3% ,简单部分性发作 (SPS)总有效率为 87.5 % ,复杂部分性发作(CPS)总有效率为 72 .0 % ,Lennox Gastaut综合征 (L GS)总有效率为 10 0 % ,其他 [包括强直性发作 (TS)、肌阵挛性发作 (MCs) ]总有效率为 85 .7% ;服药时间 1年以上者总有效率为 81.1% ,控制率为 5 2 .0 % ;单药治疗的总有效率及控制率分别为 80 .6 %、6 3.9% ,辅助治疗的总有效率及控制率分别为 82 .9%、4 1.4 % ;轻、中度病人的总有效率及控制率分别为 84 .0 %、6 6 .0 % ,重度病人的总有效率及控制率分别为 80 .3%、33.9%。结论 妥泰长期单药及辅助治疗各型癫痫效果明显、稳定 ,无耐药性 ,不良反应小 ;妥泰剂量应个体化
Objective To observe the long-term clinical application of topiramate in the treatment of epilepsy and adverse reactions. Methods A total of 118 cases of epilepsy were divided into two groups: topiramate group and topiramate group. The observation time ranged from 6 to 27 months with an average of 12.7 months. Results The effective rate of topiramate was 82.1% for all kinds of epilepsy. The total effective rate of general tonic-clonic seizure (GTCS) was 83.3% and simple partial seizure (SPS) was 87.5% The total effective rate of partial episodes (CPS) was 72.0%, and the total effective rate of Lennox Gastaut syndrome (L GS) was 100%. Other [including tonic seizure (TS) and myoclonic seizures (MCs)] The total effective rate was 85.7%; the total effective rate was 81.1% and the control rate was 52.0% when taking for more than 1 year; the total effective rate and the control rate of single drug treatment were 80.6% and 6 3.9 respectively %. The total effective rate and control rate of adjuvant therapy were 82.9% and 4 1.4% respectively. The total effective rate and control rate of mild and moderate patients were 84.0% and 6.6% respectively, The total efficiency and control rates were 80.3%, 33.9%. Conclusion High-dose long-term monotherapy and adjuvant treatment of various types of epilepsy effect was obvious, stable, non-drug resistance, adverse reactions small; topotecan dose should be individualized