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糖尿病肾病(DN)是糖尿病常见的微血管并发症,也是糖尿病患者主要致死、致残的原因。该文简要阐述了DN病理学机制不同方面的三个标志物——血清同型半胱氨酸(Hcy)、胱抑素C(CysC)和可溶性细胞间黏附分子1(sICAM-1),综述了与DN病理学机制不同角度相关的血清生物标志物及尿微量白蛋白对DN早期检测的意义,并进一步阐述联合检测对于DN早期诊断及防治的潜在价值,为今后提高DN早期检测阳性率及进一步探讨DN诊断指标提供了一定的理论依据。
Diabetic nephropathy (DN) is a common microvascular complication of diabetes and is the leading cause of death and disability in people with diabetes. This article briefly describes three markers of different aspects of DN pathology: serum homocysteine (Hcy), cystatin C (CysC) and soluble intercellular adhesion molecule 1 (sICAM-1) The significance of serum biomarkers and urine microalbumin in early detection of DN in different perspectives related to the pathological mechanism of DN and the potential value of combined detection for the early diagnosis and prevention of DN.It is of great value in improving the detection rate of DN early detection and further To explore the diagnostic index of DN provides some theoretical basis.