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干扰素有抗病毒和抗肿瘤作用,α-干扰素(IFN-α)已有效并广泛用于治疗慢性病毒性肝炎。 一名30岁妇女用IFN-α治疗慢性活动性丙型肝炎,治疗前抗甲状腺抗体滴度低,但甲状腺机能正常。用IFN-α治疗2个月后,出现甲状腺毒性:非触痛弥散性甲状腺肿。实验室检查发现,血清游离甲状腺激素水平升高,血清促甲状腺激素水平抑制。抗微粒体抗体滴度升高,抗促甲状腺激素受体抗体阴性。甲状腺~(99m)TcO闪烁图显示摄取减少。IFN-α治
Interferons have antiviral and antitumor effects and interferon-alpha (IFN-a) has been shown to be effective and widely used in the treatment of chronic viral hepatitis. A 30-year-old woman treated chronic active hepatitis C with IFN-α. Anti-thyroid antibody titer was low prior to treatment, but thyroid function was normal. Thyrotoxicity occurs after 2 months of treatment with IFN-α: non-tenderness diffuse goiter. Laboratory tests found that serum free thyroid hormone levels, serum thyroid hormone levels. Anti-microsomal antibody titers increased, anti-thyroid hormone receptor antibody negative. Thyroid ~ (99m) TcO scintigraphy shows reduced intake. IFN-α treatment