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目的:对比醋酸曲普瑞林与醋酸甲地孕酮片治疗特发性中枢性早熟的临床效果。方法:选取我院自2014年2月~2015年2月期间收治的特发性中枢性早熟患儿92例,采取随机数字表法分为2组,其中46例患儿接受醋酸甲地孕酮片治疗(对照组),46例患儿接受醋酸曲普瑞林治疗(观察组),治疗6个月后,观察对比两组患儿的生长指标及性激素水平变化,并统计其不良反应发生情况。结果:观察组治疗后的体重、身高、生长速率、预测身高、骨龄/实际年龄(BA/CA)等生长指标优于对照组(P<0.05);两组患者治疗后的雌激素(E2)、黄体生成素(LH)及促卵泡成熟素(FSH)水平较治疗前有明显改善(P<0.05),且观察组治疗后的E2、LH、FSH水平优于对照组(P<0.05);两组均未见明显不良反应发。结论:相比醋酸甲地孕酮片,醋酸曲普瑞林治疗特发性中枢性早熟患儿临床效果更好,可更好延缓患儿骨龄成熟,降低其性激素水平,在临床中具有良好的应用价值。
Objective: To compare the clinical efficacy of triptorelin acetate and megestrol acetate tablets in the treatment of idiopathic central precocious puberty. Methods: Ninety-two children with idiopathic central precocious puberty who were admitted to our hospital from February 2014 to February 2015 were randomly divided into two groups. 46 of them received megesterone acetate (Control group), 46 patients received triptorelin acetate treatment group (observation group). After 6 months of treatment, the changes of growth hormone and sex hormone levels in both groups were observed and compared, and the incidence of adverse reactions was calculated . Results: The body weight, height, growth rate, height, bone age / actual age (BA / CA) of the observation group were better than those of the control group after treatment (P < (P <0.05). The levels of E2, LH and FSH in the observation group were better than those in the control group (P <0.05). The levels of LH, FSH in the observation group were significantly higher than those in the control group (P < No obvious adverse reactions were found in both groups. Conclusion: Compared with megestrol acetate tablets, triptorelin acetate treatment of children with idiopathic central precocious puberty clinical effect is better, can better delay the age of children bone maturity, reduce the level of sex hormones in the clinic with good Value.