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复合型 OC 对脂蛋白代谢的影响取决于其中雌、孕激素成分的性质和剂量,OC 中所用雌激素多为炔雌醇或炔雌醇3-甲醚,其对脂蛋白代谢的影响是已知的。目前大部分 OC 所含孕激素多为19去甲睾酮衍生物,它们可引起 HDL-胆固醇降低和 LDL-胆固醇增加,这种脂蛋白成分的改变被视为动脉粥样硬化和冠心病的危险因子。Meade 等指出孕激素的剂量与其后心血管疾病的发生率有阳性相关,大部分复合型 OC 中含低剂量的孕激素,但孕激素的剂量不能太低,否则会引起突破性出血。因此最好
The effect of compound OC on lipoprotein metabolism depends on the nature and dosage of the estrogen and progestin components. The estrogen used in OC is mostly ethinylestradiol or ethinyl estradiol 3-methyl ether, and its effect on lipoprotein metabolism is Known. Most of the current OC contains progesterone, mostly 19-methyl-testosterone derivatives, they can cause HDL-cholesterol and LDL-cholesterol increase, this change in lipoprotein composition is considered atherosclerosis and coronary heart disease risk factors . Meade et al. Pointed out that the dose of progestin is positively related to the subsequent incidence of cardiovascular disease. Most of the compound OCs contain a low dose of progestin, but the dose of progestin should not be too low, otherwise it may cause breakthrough bleeding. So the best