左旋门冬酰胺酶具有抗肿瘤和免疫抑制作用。它的产生菌根据报导局限在肠道菌、结核分枝杆菌和土麴霉,其中大肠杆菌所产生的已用于白血病患者,但发现有相当范围的毒性反应。作者通过大量的微生物筛选,发现镰刀菌和子囊菌也同样能产生对 Gardner 淋巴肉瘤有抑制作用的门冬酰胺酶,这 L-asparaginase has antitumor and immunosuppressive effects. Its producing bacteria are reported to be confined to intestinal bacteria, Mycobacterium tuberculosis and soil mold, of which E. coli has been produced in patients with leukemia but found to have a substantial range of toxic reactions. Through a large number of microbial screening, the authors found that both Fusarium and Ascomycetes can also produce asparaginase that inhibits Gardner’s lymphosarcoma, which