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用染色体核型分析方法对上海6.25钴源事故5名受照者照后4~6年进行随访观察,为评价辐射对人远期健康影响提供生物学依据。方法照后第4年用常规染色方法,照后第5年用G显带法,照后第6年进而用染色体核型自动分析系统,加大分析细胞数,使结果更精确。结果根据照后4~6年的随访观察结果,证实在这些受照者所见到的畸变主要是稳定性畸变,它们的频率与原先所受剂量大小关系密切。结论随访观察表明稳定性畸变可以作为早先受照者的剂量评估用
By means of chromosome karyotype analysis, follow-up observation was conducted 4 to 6 years after irradiation of 5 irradiated persons in Shanghai 6.25 cobalt source accident, so as to provide a biological basis for evaluating the long-term health effects of radiation. Methods According to the method of conventional staining in the fourth year after irradiation, G banding method was used in the fifth year after irradiation, and the karyotype analysis system was used in the sixth year after irradiation. The number of cells was increased to make the result more accurate. Results According to the follow-up results of 4 to 6 years after follow-up, it was confirmed that the distortions seen by these recipients were mainly the stability distortions, and their frequencies were closely related to the dose received. Conclusions Follow-up observations indicate that stable aberrations can be used as dose estimates for previously irradiated subjects