论文部分内容阅读
目的探讨B7-H4在肾透明细胞癌(clear cell renal cell carcinomal,CCRCC)中表达的临床意义及可能的作用机制。方法采用免疫组化方法对40例肾透明细胞癌及15例正常肾组织中B7-H4的表达进行检测。结果 B7-H4在肿瘤组织中的表达高于正常肾组织,且差异具有显著性(P<0.05);随CCRCC核分级的升高,B7-H4的表达逐渐上调,渐进显著性(P≤0.05)。结论 B7-H4在CCRCC组织中的表达显著高于无瘤肾组织,且与CCRCC核分级关联;对B7-H4的进一步研究有望使其成为CCRCC临床诊断及预后判断的指标。
Objective To investigate the clinical significance and possible mechanism of B7-H4 expression in clear cell renal cell carcinomal (CCRCC). Methods Immunohistochemistry was used to detect the expression of B7-H4 in 40 cases of renal clear cell carcinoma and 15 cases of normal renal tissues. Results The expression of B7-H4 in tumor tissue was significantly higher than that in normal kidney tissue (P <0.05). The expression of B7-H4 was gradually up-regulated with the increase of nuclear grade of CCRCC ). Conclusions The expression of B7-H4 in CCRCC tissues is significantly higher than that in tumor-free kidney tissues and is correlated with the nuclear grade of CCRCC. Further study of B7-H4 is expected to make it an index of clinical diagnosis and prognosis of CCRCC.