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目的探讨新生儿持续肺动脉高压(PPHN)的临床特点。方法对2010年10月至2014年10月收治的132例PPHN患儿的原发疾病、治疗及转归情况进行分析。结果 132例PPHN患儿原发疾病包括:围生期窒息、胎粪吸入综合征、新生儿呼吸窘迫综合征、新生儿肺炎、湿肺、先天性膈疝、新生儿败血症等。在治疗原发疾病的同时,给予NCPAP、机械通气等支持对症治疗,64例重度PPHN给予一氧化氮(NO)吸入治疗。临床治愈88例,好转28例,死亡16例(其中13例放弃治疗死亡)。结论 PPHN病因复杂,早期诊断和及时治疗是改善预后的关键。
Objective To investigate the clinical features of neonatal persistent pulmonary hypertension (PPHN). Methods The primary disease, treatment and prognosis of 132 children with PPHN admitted from October 2010 to October 2014 were analyzed. Results 132 cases of primary disease in children with PPHN include: perinatal asphyxia, meconium aspiration syndrome, neonatal respiratory distress syndrome, neonatal pneumonia, wet lung, congenital diaphragmatic hernia, neonatal sepsis and so on. In the treatment of primary disease, given NCPAP, mechanical ventilation and other support symptomatic treatment, 64 cases of severe PPHN given nitric oxide (NO) inhalation therapy. Clinical cure 88 cases, 28 cases of improvement, 16 cases of death (including 13 cases give up the treatment of death). Conclusion The etiology of PPHN is complex. Early diagnosis and prompt treatment are the keys to improve prognosis.