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铜绿假单胞菌是临床最常见的条件致病菌之一。多重耐药的铜绿假单胞菌已经对临床抗感染治疗构成严重威胁。铜绿假单胞菌的耐药机制复杂 :(1)外膜渗透性降低和泵出机制使其天然对一些三代头孢菌素中度敏感。 (2 )对三代头孢菌素耐药最常见的原因是持续高产ＡｍｐＣβ 内酰胺酶〔
Pseudomonas aeruginosa is one of the most common opportunistic pathogens in clinical practice. Multidrug-resistant Pseudomonas aeruginosa has posed a serious threat to clinical anti-infective therapy. The mechanisms of drug resistance of Pseudomonas aeruginosa are complex: (1) The decreased permeability of the outer membrane and the pumping mechanism make it naturally moderate to some third-generation cephalosporins. (2) the third most common cause of cephalosporin resistance is sustained production of AmpC β lactamase [