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作者根据FAB的慢性粒单细胞白血病(CMML)的诊断标准:两系或两系以上的病态造血和外周血单核细胞绝对计数大于1×10~9/L及骨髓原始细胞低于20%,自1977年-1988年确诊CMML 35例。结果:男26例,女9例,年龄42-87岁(中位数71岁),首次症状到诊断CMML中位数时间为3个月,肝肿大17例,脾肿大10例,外周血有幼稚粒细胞31例,原始细胞14例,幼稚红细胞9例,巨核细胞4例,Ph~1染色体检查均阴性。12例曾用6-巯基嘌呤治疗,3例用马利兰,2例用羟基脲,另18例仅给支持疗法。35例CMML已死亡
According to FAB’s diagnostic criteria for chronic myelomonocytic leukemia (CMML), two or more lines of morbid hematopoietic and peripheral blood mononuclear cells have an absolute count greater than 1 × 10 9 / L and bone marrow blast cells less than 20% From 1977 to 1988 confirmed 35 cases of CMML. Results: There were 26 males and 9 females, aged 42-87 years (median 71 years). The median time to first diagnosis of CMML was 3 months, hepatic enlargement was 17, splenomegaly was 10, peripheral There were 31 cases of immature granulocytes in blood, 14 cases of primitive cells, 9 cases of immature erythrocytes, 4 cases of megakaryocytes, Ph ~ 1 chromosomal test were negative. 12 cases had treated with 6-mercaptopurine, 3 cases with Maryland, 2 cases with hydroxyurea, the other 18 cases were given only supportive therapy. 35 cases of CMML have died