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弥慢性细支气管炎(DPB)是以呼吸性细支气管炎为特征的下呼吸道疾患。在日本呼吸道疾病中占有重要的位置,治愈是困难的,小量EM(红霉素)治疗本病疗效甚佳,值得应用。 据调查过去对本病治疗是在发病初期(Ⅰ期)给类固醇药物。Ⅱ期以后的气道感染期,依病原菌给相应敏感的抗生素。对DPB和难治气管炎用青霉素、先锋素族及β—内酰胺类联合应用,对气道以流感杆菌属为主的可达到杀菌目的,因组织和痰液中抗菌素浓度相当可观,但很快会造成绿脓菌交替感染。如稻富等统计:以初诊到菌交替平均1年。欧美认为DPB是肺囊性纤维症,易引起绿脓菌交替感染,尤其应用抗生素是一重要成因。就1982年统计资料从发病开始5年生存率为75.2％,从初诊时计算则为42％。绿脓菌交替者约8％这时病情显著恶化、其预后不良。
Chronic bronchiolitis (DPB) is a lower respiratory tract disease characterized by respiratory bronchiolitis. In Japan, respiratory disease occupies an important position, the cure is difficult, a small amount of EM (erythromycin) treatment of the disease is very effective, it is worth applying. According to the survey of the past treatment of this disease is in the early stages of disease (Ⅰ) to steroid drugs. After the phase Ⅱ airway infection, according to the pathogen to the corresponding sensitive antibiotics. For DPB and refractory bronchitis with penicillin, Pioneer and β-lactams combined application, the main airway to Bacillus can achieve the purpose of bacteriostasis, tissue and sputum due to the considerable concentration of antibiotics, but very Pseudomonas aeruginosa will be caused by alternating infections. Such as rice rich and other statistics: the first visit to the bacteria alternate for an average of 1 year. Europe and the United States think that DPB is cystic fibrosis, easily lead to Alternaria infection, especially the use of antibiotics is an important cause. In 1982, the 5-year survival rate of statistical data from the onset of illness was 75.2% and from the time of initial diagnosis 42%. Pseudomonas aeruginosa alternates about 8% when the condition deteriorated significantly, the prognosis is poor.